Antibody responses to the capsular polysaccharide of Neisseria meningitidis serogroup B in patients with meningococcal disease
نویسندگان
چکیده
منابع مشابه
Study of various presentation forms for a peptide mimetic of Neisseria meningitidis serogroup B capsular polysaccharide.
The formulation of a broadly protective vaccine to prevent the serogroup B Neisseria meningitidis (MenB) disease is still an unmet medical need. We have previously reported the induction of bactericidal and protective antibodies against MenB after immunization of mice with a phage-displayed peptide named 4 L-5. This peptide mimics a capsular polysaccharide (CPS) epitope in MenB. With the aim of...
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The immunogenicity to several meningococcal polysaccharide-protein conjugates was evaluated in mice. The purified polysaccharide from N. meningitidis serogroup C (PsC) was linked to different quantities of outer membrane vesicle from N. meningitidis serogroup B (OMV) (3, 6 and 9 mg) as carrier protein, via carbodiimide-mediated reaction. The conjugates were inoculated in Balb/c mice in three do...
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Neisseria meningitidis strain M986, which possesses a polyanionic sialic acid capsular polysaccharide, was resistant to the bactericidal effects of normal rabbit serum, but sensitive when immune serum and complement were present. An isogenic strain PRM102, deficient in the ability to produce capsular polysaccharide, was sensitive to normal serum. Strain M986, when grown under conditions of low ...
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The N-propionylated group B meningococcal polysaccharide (NPrGBMP) mimics a unique protective epitope on the surface of group B meningococci (GBM) and Escherichia coli K1. Using a series of monoclonal antibodies (mAbs) induced by the NPrGBMP-monomeric tetanus toxoid (TT) conjugate vaccine it was demonstrated that mAbs having specificities for both extended and conventional short segments of the...
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ژورنال
عنوان ژورنال: Clinical Diagnostic Laboratory Immunology
سال: 1995
ISSN: 1071-412X,1098-6588
DOI: 10.1128/cdli.2.5.574-582.1995